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The Spectrum of Mutations in Progranulin: A Collaborative Study Screening 545 Cases of Neurodegeneration Arch Neurol 67:161-170,145, Yu,C.-E.,et al, 2010 See this aricle in Pubmed Article Abstract Pathogenic mutations were found only in FTD-spectrum cases and not in other related neurodegenerative diseases. Haploinsufficiency of GRN is the predominant mechanism leading to FTD.

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(click to filter results - removes previous filter) amyotrophic lateral sclerosis degenerative diseases of CNS dementia dementia,frontotemporal gene mutation lobar atrophy Parkinsonism syndrome progranulin

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